Capretta Group

Development of Synthetic Methodologies for the Parallel Synthesis of Bioactive Compounds

The drug discovery process relies heavily on the identification and structural modification of novel molecular entities. The use of combinatorial and parallel technologies by pharmaceutical companies have allowed them to greatly accelerate this process by generating large libraries of potentially biologically active compounds that can be screened, refined and developed into clinical candidates. At the heart of this process, however, remains the need for the development of robust, parallel methods for the synthesis of functionalized heterocycles.

The Capretta group has developed a number of heterocyclic libraries that make use of a wide range of readily available building blocks in a parallel fashion to produce a combinatorial array of pharmacologically-interesting small molecules.